An explosion occurred at the headquarters of the well-known pharmaceutical company Daidalos. A teenager was trapped in the collapsed steel frame and was unable to escape. His life was in danger. At this time, under the condition that he would not be held accountable for unlicensed medical practices, Black Jack performed a "surgery" that no one could imagine... The same disaster triggered another tragedy: a mother was seriously injured and paralyzed. In order not to burden her children, she found Dr. Chirico, who was known as the "incarnation of death", to seek euthanasia. On the other hand, in order to save her mother, her children worked day and night to save money, hoping that Black Jack would perform surgery on her mother. Watching them, Black Jack can't help but think of his own experience... Two doctors, one wants to kill, the other wants to save. On the secret island "Icarus Island", Black Jack and Chilico will have a life-and-death duel. What is the inside story of the explosion? The biggest crisis in the history of the series is approaching this genius surgeon step by step!