The National Alice Research Institute Academy is different from ordinary academies. It only recruits students with special abilities, which are called "Alice". Because her good friend Imai Hotaru (voiced by Kugimiya Rie) transferred from the countryside to Alice Academy in the city, Sakura Mikan (voiced by Uemura Kana), who did not want to be separated from Hotaru, ran away from home and followed Hotaru to the academy. But she couldn't enter without superpowers. After being rescued by the academy teacher Mr. Ming Hai (voiced by Ishida Akira), she accidentally developed Mikan's superpowers. So, by chance, Mikan also entered Alice Academy and fulfilled her wish to be with Hotaru. Life in the new school is both happy and sad. Mikan's superpowers are ridiculed by classmates as the most useless abilities. Her partner is the problem teenager Hinata Jujube (voiced by Park Lumei). She can't see her grandfather who depends on each other for life. In the face of various setbacks and difficulties, Mikan still responds optimistically, gradually wins everyone's love, and also gains love with Jujube, but there are still various difficulties waiting for them on the road ahead...