A gunshot in the early morning broke the long-standing peace of the Wisteria community. Mary Alice Young (Brenda Strong) committed suicide at home. The story begins with her narration. After her death, Mary began to look around and care about the lives of her neighbors: Susan (Teri Hatcher) is a children's literature writer who has no resistance to men. Her husband was divorced by Susan because of his cheating. She has a 15-year-old daughter Julie who is in adolescence. Lynette (Felicity Huffman) is a standard strong woman. She conflicts with her husband over who will take care of the four young children in the family. Bree (Marcia Cross) is a perfect housewife. She has high demands on her words and deeds, but always ignores the need for love from her husband and children. She is very elegant, but cold. The sexy Gabrielle (Eva Longoria) has a rich and interesting husband, Calos, but she always can't resist the temptation to have an affair and value material enjoyment. She also has her own unknown past. Mary's death makes these housewives start to reflect on their daily lives and make an appointment to confide in each other. But they gradually discover that there is a shocking secret behind Mary's death, and the new neighbor Mike seems to be related to this matter...