The Avengers and the subsequent far-reaching New York War made aliens and superpowers no longer secrets in the legends. After the New York War, the world pattern is about to be reshuffled, the ambitious people are ready to move, and S.H.I.E.L.D. faces unprecedented challenges. At this critical juncture, Agent Phil Coulson (Clark Gregg), who was once rumored to have died in New York, "resurrected" and absorbed Grant Ward (Brett Dalton), Melinda May (Ming-Na Wen), Leo Fitz (Iain De Caestecker), Gemma Simmons (Elizabeth Henstridge), who have special skills, and Skye (Chloe Bennett) from the hacker civil group Tide Organization. With their own mortal power, they are involved in the investigation of various incredible and suspicious dangerous events...